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UNIL | Serval
ORCID
2024
Journal of Experimental Medicine
Boeszoermenyi Andras, Bernaleau Léa, Chen Xudong, Kartnig Felix, Xie Min, Zhang Haobo, Zhang Sensen, Delacrétaz Maeva, Koren Anna, Hopp Ann-Katrin, Dvorak Vojtech, Kubicek Stefan, Aletaha Daniel, Yang Maojun, Rebsamen Manuele*, Heinz Leonhard X.*, Superti-Furga Giulio* CCDC134 controls TLR biogenesis through the ER chaperone Gp96
2023
Nature communications
Chen X.*, Xie M.*, Zhang S.*, Monguió-Tortajada M., Yin J., Liu C., Zhang Y., Delacrétaz M., Song M., Wang Y., D. L., Ding Q., Zhou B.,Tian X., Deng H., Xu L., Liu X., Yang Z., Chang Q., Na Jie, Zeng W., Superti-Furga G., Rebsamen M., Yang M. Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling
2023
Nature communications
Boeszoermenyi A.*, Bernaleau L.*, Chen X., Kartnig F., Xie M., Zhang H., Zhang S., Delacrétaz M., Koren A., Hopp A.K., Dvorak V., Kubicek S., Aletaha D., Yang M., Rebsamen M. #, Heinz L.X. #, Superti-Furga G. # A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity
2023
Cell Reports
Zhang H., Bernaleau L., Delacrétaz M., Hasanovic E., Drobek A., Eibel H., Rebsamen M. SLC15A4 controls endolysosomal TLR7–9 responses by recruiting the innate immune adaptor TASL
2022
Life Science Alliance
Rebsamen M.* ,#, Girardi E.*, Sedlyarov V., Scorzoni S., Papakostas K., Vollert M., Konecka J., Guertl B., Klavins K., Wiedmer T., Superti-Furga G. # Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
2020
Nature communications
Girardi E., Agrimi G., Goldmann U., Fiume G., Lindinger S., Sedlyarov V., Srndic I., Gürtl B., Agerer B., Kartnig F., Scarcia P., Di Noia M.A., Liñeiro E., Rebsamen M., Wiedmer T., Bergthaler A., Palmieri L., Superti-Furga G. Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
2020
Molecular systems biology
Meixner E., Goldmann U., Sedlyarov V., Scorzoni S., Rebsamen M., Girardi E., Superti-Furga G. A substrate-based ontology for human solute carriers
2020
Nature
Heinz L.X., Lee J., Kapoor U., Kartnig F., Sedlyarov V., Papakostas K., César-Razquin A., Essletzbichler P., Goldmann U., Stefanovic A., Bigenzahn J.W., Scorzoni S., Pizzagalli M.D., Bensimon A., Müller A.C., King F.J., Li J., Girardi E., Mbow M.L., Whitehurst C.E., Rebsamen M. #, Superti-Furga G. # TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
2019
Biochimica et Biophysica Acta (BBA) – Biomembranes
Scalise M, Galluccio M, Pochini L, Cosco J, Trotta M, Rebsamen M, Superti-Furga G, Indiveri C. Insights into the transport side of the human SLC38A9 transceptor
2019
Cell Death and Differentiation
Fauster A*, Rebsamen M* ,#, Willmann KL, César-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hörmann K, Heinz LX, Boztug K, Superti-Furga G. # Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking
2018
Science
Bigenzahn JW, Collu GM, Kartnig F, Pieraks M, Vladimer GI, Heinz LX, Sedlyarov V, Schischlik F, Fauster A, Rebsamen M, Parapatics K, Blomen VA, Müller AC, Winter GE, Kralovics R, Brummelkamp TR, Mlodzik M, Superti-Furga G. LZTR1 is a regulator of RAS ubiquitination and signaling
2018
Cell Host Microbe
Sedlyarov V*, Eichner R*, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, Srndic I, Moskovskich A, Heinz LX, Kartnig F, Bigenzahn JW, Rebsamen M, Kovarik P, Demaurex N, Superti-Furga G. The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
2017
Journal of Cell Biology
Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
2016
NPJ Systems Biology and Applications
Kandasamy RK, Vladimer GI, Snijder B, Müller AC, Rebsamen M, Bigenzahn JW, Moskovskich A, Sabler M, Stefanovic A, Scorzoni S, Brückner M, Penz T, Cleary C, Kralovics R, Colinge J, Bennett KL, Superti-Furga G. A time-resolved molecular map of the macrophage response to VSV infection
2016
Molecular and Cellular Proteomics
Bigenzahn JW*, Fauster A*, Rebsamen M, Kandasamy RK, Scorzoni S, Vladimer GI, Müller AC, Gstaiger M, Zuber J, Bennett KL, Superti-Furga G. An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client
2015
Cell Reports
Heinz LX*, Baumann CL*, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
2015
Cell Death and Disease
Fauster A*, Rebsamen M*, Huber KV, Bigenzahn JW, Stukalov A, Lardeau C, Scorzoni S, Bruckner M, Gridling M, Parapatics K, Colinge J, Bennett KL, Kubicek S, Krautwald S, Linkermann A, Superti-Furga G. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis
2015
ACS Chemical Biology
Dixon SJ*, Winter GE*, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
2015
Nature
Rebsamen M, Pochini L, Stasyk T, de Araújo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
2013
Nature Methods
Bürckstümmer T, Banning C, Hainzl P, Schobesberger R, Kerzendorfer C, Pauler FM, Chen D, Them N, Schischlik F, Rebsamen M, Smida M, Fece de la Cruz F, Lapao A, Liszt M, Eizinger B, Guenzl PM, Blomen VA, Konopka T, Gapp B, Parapatics K, Maier B, Stöckl J, Fischl W, Salic S, Taba Casari MR, Knapp S, Bennett KL, Bock C, Colinge J, Kralovics R, Ammerer G, Casari G, Brummelkamp TR, Superti-Furga G, Nijman SM. A reversible gene trap collection empowers haploid genetics in human cells
2013
Trends in Immunology
Rebsamen M, Kandasamy RK, Superti-Furga G. Protein interaction networks in innate immunity
2012
Cell Death and Differentiation
Heinz LX, Rebsamen M, Rossi DC, Staehli F, Schroder K, Quadroni M, Gross O, Schneider P, Tschopp J. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade
2012
Journal of Immunology
Staehli F, Ludigs K, Heinz LX, Seguín-Estévez Q, Ferrero I, Braun M, Schroder K, Rebsamen M, Tardivel A, Mattmann C, MacDonald HR, Romero P, Reith W, Guarda G, Tschopp J. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells
2011
Cell Death and Differentiation
Rebsamen M #, Vazquez J, Tardivel A, Guarda G, Tschopp NLRX1/NOD5 deficiency does not affect MAVS signaling
2010
Cell Cycle
2010
Nature Immunology
Poeck H*, Bscheider M*, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
2009
EMBO Reports
Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
2008
Cell Death and Differentiation
2008
Immunity
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, König M, Kalinke U, Pasparakis M, Tschopp J. TRADD protein is an essential component of the RIG-like helicase antiviral pathway
Other relevant publications:
2024
PTC application (WO2024089045A1)
Boeszoermenyi A, Heinz L, Rebsamen M, Superti-Furga G. TASL mimicking molecules and applications thereof
2015
PTC application (WO2015173398)
Rebsamen M, Superti-Furga G. Antagonists of SLC38A9 and their use in therapy
2010
Doctoral Thesis
Rebsamen M. Characterization of cytoplasmic antiviral signaling pathways